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IgG Food Sensitivity testing

IgG Food Sensitivity testing

Elevated IgG antibodies can promote systemic (whole-body) inflammation, leading to a variety of unwanted symptoms.


IgG Food Explorer tests immunoglobulin (IgG) antibodies to over 250 common foods. This extensive food sensitivity test can help practitioners pinpoint which foods may be driving symptoms and best prioritize and individualize a diet and lifestyle plan for patients.

Usually, eliminating foods that promote an IgG antibody response can reduce stress on the immune system, lower whole-body inflammation, and help heal the gut. An antibody-guided elimination diet is more reliable and preferable than generalized diet plans or exclusion diets based on food journaling and diet history alone.

IgG Food Explorer provides in-depth insight into adverse food reactions and the symptoms they create.


Symptoms of food sensitivity may be Gut-Related Symptoms or Extraintestinal, but are not limited to the following:

• Bloating

• Diarrhea

• Nausea

• Constipation

• Reflux

• Irritable Bowel Syndrome (IBS)

• Autoimmune conditions

• Skin symptoms, including:

– Eczema

– Atopic dermatitis

– Rashes and urticaria

– Bags under eyes

• Headaches/migraines

• Blood sugar imbalances


• Musculoskeletal/Joint pain

• Food Cravings

• Behavioral symptoms, including:

– Anxiety

– Attention Deficit Hyperactivity Disorder (ADHD)

– Mood swings

– Autism Spectrum Disorder (ASD)


IgG-mediated food sensitivities are often a consequence of poor gut health, poor digestion, dysbiosis, and inflammation – all of which can result in intestinal permeability or "leaky gut." If the gut barrier is permeable and or digestion is suboptimal, maldigested food proteins can leak across the intestinal barrier.

Since gut permeability is not normal physiology, the immune system may detect food protein molecules as foreign or antigenic. T cells then become sensitized and begin the immune response to produce antibodies against these foods. This phenomenon is called the loss of oral tolerance to a particular food.

Food sensitivities and loss of intestinal barrier function is a well-understood connection in functional medicine. However, it is crucial to keep in mind that the intestinal cell barrier is made up of highly interactive layers, including the following:

  • Microbiota/Bacteria
  • Mucous layers
  • Epithelium (includes tight junctions)
  • Immune system

A compromise to any of these layers can propagate intestinal permeability. Tight junctions are an important but are not the entire picture when considering a compromised gut barrier.

IgG Food Explorer testing for food sensitivities can not only help pinpoint trigger foods that may be exacerbating a patient’s symptoms but can provide essential clues about gut dysfunction, digestive insufficiency, and intestinal permeability.


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